THR are reporting that FOX are actively moving forward with PROMETHEUS 2 and are eying a 2014 or 2015 release. Original screenwriter (or script doctor) Damien Lindelof is not confirmed to return and Fox is out there speaking to potential writers.
PROMETHEUS certainly split the audience, some people loved it and others (including me) thought it was plot hole laden rubbish with inept characters and great visual effects. Seriously, Charlize, you can only run in one direction? Anyways, P2 is on the way peoples.